This video provides approximately 15-minute didactic overview of how and when to use blood levels and basic clozapine pharmacokinetics with a focus on making sure the participants learn how to apply knowledge of clozapine metabolism and metabolic ratios to make decisions regarding adherence or unusual drug metabolism, understand clozapine metabolism and kinetics to make decisions regarding the introduction or withdrawal of strong inhibitors and inducers, and apply knowledge of clozapine metabolism and kinetics to safely adjust dosage when a serious infection is present. This is followed by a discussion on the topic between the presenter, other experts and providers.
Session 22: Drug Interactions with Clozapine (70 minutes) Jonathan Meyer
This video provides approximately 15-minute didactic overview of drug interactions with clozapine with a focus on making sure the participants learn how to understand the potential pharmacokinetic drug interactions with clozapine and the mechanisms for these interactions, recognize the role and extent of cigarette smoking as a pharmacokinetic interaction with clozapine, understand the role of pharmacodynamic drug interactions with clozapine and strategies to minimize this effect. This is followed by a discussion on the topic between the presenter, other experts and providers.
Session 23: Clozapine and Augmentation Options (34 minutes)
This video provides approximately 15-minute didactic overview of clozapine and augmentation options with a focus on making sure the participants learn how to list the indications for an augmentation strategy in a clozapine-treated patient, describe non-pharmacological augmentation strategies for clozapine-treated patients, and discuss evidence-based pharmacological augmentation strategies for clozapine-treated patients. This is followed by a discussion on the topic between the presenter, other experts and providers.