This video provides an approximately 15-minute didactic overview of how to determine if someone has treatment-resistant schizophrenia with a focus on making sure the participants learn how to list the criteria by which a patient is determined to have treatment-resistant schizophrenia, describe other reasons that may impact optimal treatment response, and differentiate between treatment-resistant symptoms and inadequate medication trials. This is followed by a discussion on the topic between the presenter, other experts and providers.
Session 9: How and When to Use Clozapine Blood Levels (54 minutes)
This video provides approximately 15-minute didactic overview of how and when to use blood levels and basic clozapine pharmacokinetics with a focus on making sure the participants learn how to apply knowledge of clozapine metabolism and metabolic ratios to make decisions regarding adherence or unusual drug metabolism, understand clozapine metabolism and kinetics to make decisions regarding the introduction or withdrawal of strong inhibitors and inducers, and apply knowledge of clozapine metabolism and kinetics to safely adjust dosage when a serious infection is present. This is followed by a discussion on the topic between the presenter, other experts and providers.
Session 10: Clozapine and Constipation: Monitoring, Prevention, Acute Treatment and Patient Communication (45 minutes)
This video provides approximately 15-minute didactic overview of clozapine and constipation: monitoring, prevention, acute treatment and patient communication with a focus on making sure the participants learn how to describe recommendations to prevent constipation in clozapine-treated patients, list the monitoring parameters for constipation, outline the acute treatment options for constipation in clozapine-treated patients, and discuss how to communicate with patients about constipation. This is followed by a discussion on the topic between the presenter, other experts and providers.
Session 11: Tachycardia, orthostatic hypotension, syncope, and sedation with clozapine (38 minutes)
This video provides approximately 15-minute didactic overview of tachycardia, orthostatic hypotension, syncope side effects, and sedation with clozapine with a focus on making sure the participants learn how to recognize common adverse effects with clozapine and their associated prevalence, understand the relationship of dosing to sedation, orthostasis and tachycardia, and discern treatment strategies to manage these adverse drug reactions. This is followed by a discussion on the topic between the presenter, other experts and providers.