This video provides an approximately 15-minute didactic overview of how to determine if someone has treatment-resistant schizophrenia with a focus on making sure the participants learn how to list the criteria by which a patient is determined to have treatment-resistant schizophrenia, describe other reasons that may impact optimal treatment response, and differentiate between treatment resistant symptoms and inadequate medication trials. This is followed by a discussion on the topic between the presenter, other experts and providers.